Biphasic Mechanism of Action
Most dry eye drops simply add volume to the tear film, providing only short-term relief. As soon as the moisture dissipates, the symptoms return. SYSTANE® Lubricant Eye Drops actually prolong tear film break-up time (TFBUT) with a unique biphasic mechanism of action (MOA)4. As a result, SYSTANE® offers long-lasting symptom relief and an enhanced environment for ocular surface repair.
SYSTANE® eye drops contain a unique gelling and lubricating polymer system formulated to adjust to each patient's individual tear film pH. This ensures optimum performance and provides enhanced relief for a patient's specific physiological needs.

The polymerizing protection of SYSTANE® is achieved through the interaction of soothing demulcents (polyethylene glycol 400 and propylene glycol), HP-Guar and the patient's own natural tears.
When the HP-Guar in SYSTANE® eye drops combines with certain elements found in the tears, a chemical reaction occurs. HP-Guar binds to the hydrophobic (water-repelling) corneal surface, forming a surface-anchored network with a gel-like consistency. By cross-linking with borate ions, HP-Guar helps keep the demulcent system (polyethylene glycol / propylene glycol) on the surface of the eye longer, providing long-lasting relief from the symptoms of dry eye.
At the same time, SYSTANE® also helps create an ocular shield, allowing for epithelial repair in a healthy and protected environment. The protection of SYSTANE® Lubricant Eye Drops provides long lasting relief and sustained comfort.
Back to the Top- Survey of Ophthalmologists and Optometrists, Harris Interactive® November, 2007
- Christensen MT, Cohen S, Rinehart J, Akers F, Pemberton B, Bloomenstein M, Lesher M, Kaplan D, Meadows D, Meuse P, Hearn C, Stein JM. Clinical evaluation of an HP-Guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004. Jan;28(1):55-62.
- Torkildsen G MD, Colby K MD, PhD, Corbin G, OD. The Effect of Systane Compared to Marketed Artificial Tears on Drop Preference American Academy of Optometry, Denver 2006.
- D'Arienzo P, Ousler GW, Schindelar MS. A comparison of two marketed artificial tears in improvement of tear film stability as measured by tear film break-up time (TFBUT) and ocular protection index (OPI). Poster presentation, Tear Film and Ocular Surface Society Meeting 2007, Taormina, Sicily.