SYSTANE® Products

SYSTANE® Lubricant Eye Drops

SYSTANE® Lubricant Eye Drops

The #1 Doctor Recommended artificial tear1, SYSTANE® Lubricant Eye has been clinically proven2 to reduce both the measurable signs and patient-described symptoms of dry eye. Providing immediate, long-lasting moisture and protection, it's no wonder that SYSTANE® is preferred nearly 2 to 13 over other dry eye treatments on the market. When patients seek relief, recommend SYSTANE® Lubricant Eye Drops as their first-line dry eye treatment.

Biphasic Mechanism of Action

Most dry eye drops simply add volume to the tear film, providing only short-term relief. As soon as the moisture dissipates, the symptoms return. SYSTANE® Lubricant Eye Drops actually prolong tear film break-up time (TFBUT) with a unique biphasic mechanism of action (MOA)4. As a result, SYSTANE® offers long-lasting symptom relief and an enhanced environment for ocular surface repair.

SYSTANE® eye drops contain a unique gelling and lubricating polymer system formulated to adjust to each patient's individual tear film pH. This ensures optimum performance and provides enhanced relief for a patient's specific physiological needs.

Mechanism of Action

The polymerizing protection of SYSTANE® is achieved through the interaction of soothing demulcents (polyethylene glycol 400 and propylene glycol), HP-Guar and the patient's own natural tears.

When the HP-Guar in SYSTANE® eye drops combines with certain elements found in the tears, a chemical reaction occurs. HP-Guar binds to the hydrophobic (water-repelling) corneal surface, forming a surface-anchored network with a gel-like consistency. By cross-linking with borate ions, HP-Guar helps keep the demulcent system (polyethylene glycol / propylene glycol) on the surface of the eye longer, providing long-lasting relief from the symptoms of dry eye.

At the same time, SYSTANE® also helps create an ocular shield, allowing for epithelial repair in a healthy and protected environment. The protection of SYSTANE® Lubricant Eye Drops provides long lasting relief and sustained comfort.

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  1. Survey of Ophthalmologists and Optometrists, Harris Interactive® November, 2007
  2. Christensen MT, Cohen S, Rinehart J, Akers F, Pemberton B, Bloomenstein M, Lesher M, Kaplan D, Meadows D, Meuse P, Hearn C, Stein JM. Clinical evaluation of an HP-Guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004. Jan;28(1):55-62.
  3. Torkildsen G MD, Colby K MD, PhD, Corbin G, OD. The Effect of Systane Compared to Marketed Artificial Tears on Drop Preference American Academy of Optometry, Denver 2006.
  4. D'Arienzo P, Ousler GW, Schindelar MS. A comparison of two marketed artificial tears in improvement of tear film stability as measured by tear film break-up time (TFBUT) and ocular protection index (OPI). Poster presentation, Tear Film and Ocular Surface Society Meeting 2007, Taormina, Sicily.

Patient: Female, 34

Symptoms: Watery, gritty eyes; foreign body sensation

Diagnosis: Dry Eye Syndrome, exacerbated by environment

Treatment: SYSTANE® Lubricant Eye Drops

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SYSTANE® Lubricant Eye Drops helps protect eyes from dry eye and keeps them lubricated throughout the day.

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