Scientific Data

Study Summary1

SYSTANE® Lubricant Eye Drops is more effective than Refresh Tears* at reducing the signs and symptoms associated with dry eye problems.

Figure 1. Mean agreement to a Likert Scale questions [range: strongly disagree (0) to strongly agree (5)] at the exit visit. In response to the question, "My eyes feel dry in the morning", mean response among subjects using SYSTANE® or Refresh Tears* was 3.4 ± 1.3 and 4.0 ± 1.1, respectively (†p = 0.015). In response to the question, "My eyes feel dry at the end of the day", mean response among subjects using SYSTANE® or the Refresh Tears* was 3.3 ± 1.4 and 3.9 ± 0.9, respectively (†p = 0.023). Asterisks indicate statistically significant decreases in dryness.

Figure 2. Mean response to the visual analog question, "How often do you experience foreign body sensation" [range:0 (did not occur) to 5 (continuous)]. Mean response among subjects using the SYSTANE® was statistically different compared to subjects using Refresh Tears* (p = 0.033).


SYSTANE® significantly reduced symptoms of dryness in the morning and evening, compared to Refresh Tears* (p = 0.015 and p = 0.023, respectively) (Figure 1).

Subjects in the group using SYSTANE® also reported lower frequencies of foreign body sensation (Figure 2) and felt their eyes were "refreshed longer" compared to those in the REFRESH TEARS* group (p = 0.033 and p = 0.037 respectively).

The observed efficacy differences could be attributed to the differences in formulations with respect to preservatives, demulcents, viscosity, active ingredients and excipients. SYSTANE® is preserved with POLYQUAD®, while Refresh Tears* is preserved with Purite*. Both preservatives have shown to be safe and have been used in numerous ophthalmic formulations for several years.

The difference in viscosity between the two products may account for some of the observed effects. The viscosities of the solutions are approximately l0 cps and 3 cps for SYSTANE® and Refresh Tears* respectively. A unique attribute of SYSTANE® is the addition of HP-Guar as a gelling agent, which is pH sensitive. When exposed to the ocular pH viscosity increases significantly.

For a more detailed summary of this study, click on the "View Summary" button below.

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  1. Christensen MT, Cohen S, Rinehart J, Akers F, Pemberton B, Bloomenstein M, Lesher M, Kaplan D, Meadows D, Meuse P, Hearn C, Stein JM. Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004. Jan;28(1):55-62.

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SYSTANE®

SYSTANE®

SYSTANE® Lubricant Eye Drops helps protect eyes from dry eye and keeps them lubricated throughout the day.

Learn More
SYSTANE®

SYSTANE®

SYSTANE® Lubricant Eye Drops helps protect eyes from dry eye and keeps them lubricated throughout the day.

Learn More