Scientific Data

Clinical Data

The following clinical studies support the claims of SYSTANE® Eye Drops. To view an available summary of an abstract, click on the hyperlinked study title.

SYSTANE® Lubricant Eye Drops

  1. Christensen MT, Cohen S, Rinehart J, Akers F, Pemberton B, Bloomenstein M, Lesher M, Kaplan D, Meadows D, Meuse P, Hearn C, Stein JM. Clinical evaluation of an HP-Guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004. Jan;28(1):55-62. Study summary information
  2. Przydryga J, Hartstein I, Khwarg S. An open label evaluation of HP-Guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population. Curr Eye Res Opin. 2005; 21 (2): 255-260. View Poster
  3. Meadows DL, Ketelson HA. Physical/Chemical Characteristics of the Human Tear Film that Impacts Performance & Efficacy of Artificial Tear Products. Tear Film and Ocular Surface Society 2004.

SYSTANE® Extends Tear Film Break-up Time

  1. Gifford P, Evans BJ, Morris J. A clinical evaluation of Systane. Contact Lens Anterior Eye 2006;29:31-40.
  2. Ousler GW, Michaelson C, Christensen MT. An Evaluation of Tear Film Break-up Time Extension and Ocular Protection Index Scores between Three Marketed Lubricant Eye Drops. Cornea. In Press.
  3. Christensen MT, Stein JM, Stone RP, Meadows DL. Evaluation of the effect on tear film break-up time extension by artificial tears in dry eye patients. Presented at: 23rd Biennial Cornea Research Conference; October 3-4, 2003; Boston, Mass.
  4. Ousler GW, Emory TB, Welch D, Abelson MB. Factors that influence the inter-blink interval (IBI) as measured by the ocular protection index (OPI). Presented at: The Association of Research in Vision and Ophthalmology (ARVO); 2002.
  5. Nally L, Ousler GW, Abelson MB. Ocular discomfort and tear film break-up time in dry eye patients: a correlation. Invest Ophthalmol Vis Sci. 2000;41(4):1436. ARVO Abstract.
  6. Guillon M, Chamberlain P, Marks MG, Stein JM. Effect of Eye Drop Compositional Characteristics on Tear Film. Presented at: The Association of Research in Vision and Ophthalmology (ARVO); April 25-29, 2004; Fort Lauderdale, FL.
  7. D'Arienzo P, Ousler GW, Schindelar MS. A comparison of two marketed artificial tears in improvement of tear film stability as measured by tear film break-up time (TFBUT) and ocular protection index (OPI). Poster presentation, Tear Film and Ocular Surface Society Meeting 2007, Taormina, Sicily.

SYSTANE® Compatibility with Restasis*

  1. Sall KN, Cohen SM, Christensen, MT, Stein JM. An Evaluation of the Efficacy of a Cyclosporine-Based Dry Eye Therapy when used with Marketed Artificial Tears as Supportive Therapy in Dry Eye. Eye & Contact Lens. 2006;32(1):21-26.
  2. RESTASIS* prescribing information.

SYSTANE® Lubricity

  1. Ketelson HA, Asgharian B, Chowhan M, Meadows D. In-vitro Characterization of Physical Property Attributes for Polymer Systems Used in Artificial Tear Products. Abst. ARVO 2004:No 70.
  2. Korb DR, Greiner JV. Et. Al. Lid-Wiper Epitheliopathy and Dry-Eye Symptoms in Contact Lens Wearers. The CLAO J. 2002: 28(4):211-216.
  3. Korb DR, Herman JP, Greiner JV, Scaffidi RC, Finnemore VM, Exford JM, Blackie CA, Douglass T. Lid Wiper Epitheliopathy and Dry Eye Symptoms. Eye & Contact Lens 2005; 31(1):2-8.
  4. Meyer AE, Baier, RE, Chen H, Chowham, M. Tissue on tissue testing of dry eye formulations for reduction of bioadhesion. The Journal of Adhesion. 82:607-627,2006.
  5. Chen H, Gan O, Meadows D, Meyer AE, Baier RE. Evaluation of Lubricity of Marketed Dry Eye Products Using a Tissue-on-Tissue Model. Accepted to AOA 2007.
  6. Meyer AE, Baier, RE, Chen H, Chowham, M. Differential Tissue-on-Tissue Lubrication by Ophthalmic Formulations. Journal of Biomedical Materials Research: Applied Biomaterials 2007;82 (Part B):74-88.

SYSTANE® Retention Time

  1. Paugh JR, Nguyen AL, Ketelson HA, Christensen MT, Meadows DL. The pre-corneal residence time of artificial tears measured in dry eye subjects. In press.
  2. Paugh JR, Meadows D, Christensen, M. The residence time of artificial tears in dry eye subjects. Paper presented at American Academy of Optometry Annual Meeting 2005. E-abstract #050062.

SYSTANE® Efficacy After 3,5 Weeks

  1. Aguilar, A, Cohen, S, Christensen, M. Duration of the efficacy of Systane Lubricant Eye Drops in dry eye patients. Poster presented at World Ophthalmology Congress, Sao Paolo 2006.

SYSTANE® Preference

  1. Gail Torkildsen, MD, Kathryn Colby, MD, PhD, Glenn Corbin, OD The Effect of Systane Compared to Marketed Artificial Tears on Drop Preference. Poster presented at American Academy of Optometry 2006.
  2. Carol Fairchild, Ph.D., Elizabeth Power, M.B.A., Ram Rao, B.A. , and Gail King, M.B.A.. Dry Eye (DE) Treatment: Patient's Perspective. Poster presented at American Academy of Optometry 2006.

SYSTANE® Pre- and Post-Contact Lens Wear Improves Comfort

  1. Cohen S, Potter, W, Christensen MT. Use of SYSTANE to help reduce symptoms of dry eye associated with contact lens wear. Presented at: the 107th Annual American Optometric Association Congress; June 23-27, 2004; Orlando, FL.

Ocular Protection Index

  1. Ousler GW, Emory TB, Welch D, Abelson MB. Factors that influence the inter-blink interval (IBI) as measured by the ocular protection index (OPI). (Poster presentation) The Association of Research in Vision and Ophthalmology (ARVO), 2002.
  2. Nally L, Ousler GW, Abelson MB. Ocular discomfort and tear film break-up time in dry eye patients: a correlation. IOVS 2000 41;4(ARVO Abstract):1436.

Glycocalyx

  1. Korb DR, Craig J, Doughty M, Guillon J, Smith G, Tomlinson A. The Tear Film: Structure, Function and Clinical Examination. BCLA, 2002.

Tear pH

  1. Yamada M., Mochizuki H., et al. Fluorophotometric Measurement of pH of Human Tears In Vivo. Current Eye Research 1997;16(5):482-486.
  2. Maurice DM. The Charles Prentice Award Lecture 1989: The Physiology of Tears. Optometry & Vision Science 1990;67(6):391-399.

#1 Doctor Recommended

  1. Survey of Ophthalmologists and Optometrists, Harris Interactive, November 2007.

SYSTANE®

SYSTANE®

SYSTANE® Lubricant Eye Drops helps protect eyes from dry eye and keeps them lubricated throughout the day.

Learn More
SYSTANE®

SYSTANE®

SYSTANE® Lubricant Eye Drops helps protect eyes from dry eye and keeps them lubricated throughout the day.

Learn More